The Clinton Redskins (12-0) will play Grand Rapids NorthPointe Christian at noon on Saturday at Battle Creek Harper Creek High School on Saturday.
The Redskins are playing in the semifinals for the second time in three years.
The other semifinal matchup in Division 6 is Traverse City St. Francis against Ithaca. Those teams meet at Clare at 1 p.m. Saturday.
All four teams remaining in D6 are unbeaten.